Yesterday, we ran the story of Damon Lindelof talking about the evolution of the original Alien prequel script to what's being used for Prometheus. He confirmed that the film was still taking place in the "Alien" universe, but also mentioned that it would not feature certain staples of the series, such as facehuggers and chestbursters.
Ridley Scott talked a bit more about Prometheus during a Q&A session at CineEurope, and THR was there to cover it:
"Scott acknowledged that Prometheus, while not a direct prequel to Alien, occupies the same general universe, saying the picture was inspired by a desire to explore the mystery of the "space jockey" the giant fossilized creature with the burst-open chest seen in the first Alien movie but never explained. Scott also confirmed that the film's title is the name of a space ship sent from earth by an all-powerful corporation of the kind familiar to fans of the Alien franchise. "
Although previously leaked reports mentioned the space jockey already, it's nice to have some confirmation from Ridley Scott, as well as the acknowledgement that this is still tied to the Alien universe. Hit up the source link below, for some additional quote from Michael Fassbender and Noomi Rapace, who were also in attendance.