We haven't heard much about The Human Centipede 3 (Final Sequence) since it started filming in California last year, but the first photo has just been released. According to Tom Six (via EW) the movie will be released later this year and will be quite different from the first two installments:

“THC Part 3 will be totally different from Parts 1 and 2 and certainly not as gross... But it will be the most controversial one politically-wise. It will have a lot of self-mockery and will be the most darkly comical of the three. Parts 1 and 2 have a very European feel. Part 3 is very American with the highest budget, a big movie score, widescreen, and an XXL human centipede. It’s set in an American maximum security prison in the middle of the desert. Plot-wise I won’t share details yet but if you let your imagination run wild you might get ideas.”

It has also been confirmed that Tom Six did move forward with his previously announced plan to put together a 500-person human centipede. The photo shows the return of Laurence R. Harvey and Dieter Laser, and the cast also includes Eric Roberts, Tommy “Tiny” Lister (Friday), Robert LaSardo (Death Race, Nip/Tuck), Bree Olson, and Tom Six.

Source: EW