If Scream 4 is successful, it looks like Scream 5 and 6 are very likely. Scream Trilogy grabbed a few quotes from the upcoming issue of Total Film, including talk about future sequels from Wes Craven:
"And would Craven be up for any more if this Screamed up enough box office? 'When I initially met with Kevin, he sketched out what the next two would be, and I found it really fascinating,' he concludes. 'A lot depends on whether they come up with scripts to flesh out. But certainly, I’m up for it, if the script is there. It’s a fascinating thing to do two trilogies in a career.' "
We won't have to wait too much longer to see how Scream 4 does at the box office, as it will be released almost one month from now, on April 15th.