With the success of Zombieland, a sequel seemed likely and there was even talk about possibly turning it into a TV series. If you've been hoping for a sequel, it's looking less likely based on recent comments from Zombieland director Ruben Fleischer.
While talking with Collider, Fleischer confirmed that there are no plans to make a sequel at this time:
“I hate to do it, but I can say that there’s no immediate plans to make the movie. There’s no script, really, so the likelihood of it happening is slim. But I would not wanna put a nail in that coffin.”
He also mentioned that the reason for no sequel wasn't anything on the studio's part, but not coming up with a great sequel idea:
“Well I think that the studio would be very excited to make it. It’s not that the studio is not excited, it’s that we took one shot at the script [and] it wasn’t something we all got excited to do. And just on a personal level, I was really excited to, having made one movie, to make different movies, not just go back into that world again. But now that I have some distance and I’ve done some other stuff, I would be more inclined to go back to Zombieland I guess you could say. But at the time when the talk of the sequel was really—when it felt like it was possible—I was really kind of shying away from it just because I’ve only made one movie, I wanna make different movies with different people and learn different things, and so I was a little hesitant to just jump right back into the same thing.”
To read about what he had in mind for the sequel story, head over to Collider.